• Corpus ID: 254564573

Ensemble reweighting using Cryo-EM particles

  title={Ensemble reweighting using Cryo-EM particles},
  author={Wai Shing Tang and David Silva-S'anchez and Julian Giraldo-Barreto and Bob Carpenter and Sonya M. Hanson and Alex H. Barnett and Erik H. Thiede and Pilar Cossio},
Cryo-electron microscopy (cryo-EM) has recently become a premier method for obtaining high-resolution structures of biological macromolecules. However, it is limited to biomolecular samples with low conformational heterogeneity, where all the conformations can be well-sampled at many projection angles. While cryo-EM technically provides single-molecule data for heterogeneous molecules, most existing reconstruction tools cannot extract the full distribution of possible molecular configurations… 
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