• Corpus ID: 235417574

Ensemble inversion for brain tumor growth models with mass effect

@article{Subramanian2021EnsembleIF,
  title={Ensemble inversion for brain tumor growth models with mass effect},
  author={Shashank Subramanian and Klaudius Scheufele and Naveen Himthani and Christos Davatzikos and George Biros},
  journal={ArXiv},
  year={2021},
  volume={abs/2106.06016}
}
We propose a method for extracting physics-based biomarkers from a single multiparametric Magnetic Resonance Imaging (mpMRI) scan bearing a glioma tumor. We account for mass effect, the deformation of brain parenchyma due to the growing tumor, which on its own is an important radiographic feature but its automatic quantification remains an open problem. In particular, we calibrate a partial differential equation (PDE) tumor growth model that captures mass effect, parameterized by a single… 

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