Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the Drosha cleavage site.

@article{Quarles2013EnsembleAO,
  title={Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the Drosha cleavage site.},
  author={Kaycee A. Quarles and Debashish Sahu and Mallory A Havens and Ellen R. Forsyth and Christopher Wostenberg and Michelle L. Hastings and Scott A Showalter},
  journal={Biochemistry},
  year={2013},
  volume={52 5},
  pages={795-807}
}
Most noncoding RNAs function properly only when folded into complex three-dimensional (3D) structures, but the experimental determination of these structures remains challenging. Understanding of primary microRNA (miRNA) maturation is currently limited by a lack of determined structures for nonprocessed forms of the RNA. SHAPE chemistry efficiently determines RNA secondary structural information with single-nucleotide resolution, providing constraints suitable for input into MC-Pipeline for… CONTINUE READING

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