Ensemble Modeling of Cancer Metabolism

@inproceedings{Khazaei2012EnsembleMO,
  title={Ensemble Modeling of Cancer Metabolism},
  author={Tahmineh Khazaei and Alison P McGuigan and Radhakrishnan Mahadevan},
  booktitle={Front. Physio.},
  year={2012}
}
The metabolic behavior of cancer cells is adapted to meet their proliferative needs, with notable changes such as enhanced lactate secretion and glucose uptake rates. In this work, we use the Ensemble Modeling (EM) framework to gain insight and predict potential drug targets for tumor cells. EM generates a set of models which span the space of kinetic parameters that are constrained by thermodynamics. Perturbation data based on known targets are used to screen the entire ensemble of models to… CONTINUE READING

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