Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells.

  title={Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells.},
  author={James R Goldenring and Carol J. Soroka and K. Robert Shen and Laura H. Tang and Williams Rodriguez and Helen Vaughan and Selwyn Aubrey Stoch and Irvin Mark Modlin},
  journal={The American journal of physiology},
  volume={267 2 Pt 1},
Parietal cell secretion of acid requires the coordinated fusion of H(+)-K(+)-adenosinetriphosphatase (ATPase)-containing tubulovesicles with a secretory canalicular target membrane. We have previously reported the presence of rab2 on parietal cell tubulovesicles (L. H. Tang, S. A. Stoch, I. M. Modlin, and J. R. Goldenring. Biochem. J. 285: 715-719, 1992). Since 60% of the small GTP-binding protein sequences obtained from parietal cells were > 95% homologous with human rab11 (J. R. Goldenring, K… CONTINUE READING
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