Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles.

@article{Mandal2013EnrichmentOP,
  title={Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles.},
  author={Prabhat Kumar Mandal and Adam D. Ewing and Dustin C. Hancks and Haig H. Kazazian},
  journal={Human molecular genetics},
  year={2013},
  volume={22 18},
  pages={3730-48}
}
Long INterspersed Elements (LINE-1s, L1s) are responsible for over one million retrotransposon insertions and 8000 processed pseudogenes (PPs) in the human genome. An active L1 encodes two proteins (ORF1p and ORF2p) that bind with L1 RNA and form L1-ribonucleoprotein particles (RNPs). Although it is believed that the RNA-binding property of ORF1p is critical to recruit other mobile RNAs to the RNP, the identity of recruited RNAs is largely unknown. Here, we used crosslinking and… CONTINUE READING
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