Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity

@inproceedings{Yu2013EnrichmentOH,
  title={Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity},
  author={Ling Yu and Shi-qing Liu and Chun Xiao Zhang and Bo Zhang and Bruno M. Sim{\~o}es and Rachel Eyre and Yi Liang and Huichao Yan and Zheng Wu and Weichun Guo and Robert B. Clarke},
  booktitle={Oncotarget},
  year={2013}
}
Telomerase is crucial for the maintenance of stem/progenitor cells in adult tissues and is detected in most malignant cancers, including osteosarcoma. However, the relationship between telomerase expression and cancer stem cells remains unknown. We observed that sphere-derived osteosarcoma cells had higher telomerase activity, indicating that telomerase activity might be enriched in osteosarcoma stem cells. We sorted subpopulations with high or low telomerase activity (TEL) using hTERT… CONTINUE READING