Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma.

@article{Choi2005EnrichmentOF,
  title={Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma.},
  author={Carmen Choi and Mathias Witzens and Marianna Bucur and Markus Feuerer and Nora Sommerfeldt and Andreas Trojan and Anthony Yuk-Kwan Ho and Volker Schirrmacher and Hartmut Goldschmidt and Philipp Beckhove},
  journal={Blood},
  year={2005},
  volume={105 5},
  pages={2132-4}
}
Multiple myeloma (MM) is one of the most common hematologic malignancies. Despite extensive therapeutical approaches, cures remain rare exceptions. An important issue for future immunologic treatments is the characterization of appropriate tumor-associated antigens. Recently, a highly glycosylated mucin MUC1 was detected on a majority of multiple myeloma cell lines. We analyzed bone marrow and peripheral blood of 68 patients with HLA-A2-positive myeloma for the presence and functional activity… CONTINUE READING
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