Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells.

@article{Heemskerk1999EnrichmentOA,
  title={Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells.},
  author={Mirjam H. M. Heemskerk and Erik Hooijberg and Janneke J. Ruizendaal and Marchien van der Weide and Esther W. M. Kueter and Arjen Q. Bakker and Ton N M Schumacher and Hergen Spits},
  journal={Cellular immunology},
  year={1999},
  volume={195 1},
  pages={10-7}
}
The superior ability of dendritic cells (DC) in triggering antigen-specific T cell responses makes these cells attractive tools for the generation of antitumor or antiviral immunity. We report here an efficient retroviral transduction system for the introduction of antigens into DC. A retroviral vector encoding several CTL epitopes in a string-of-beads fashion in combination with the marker gene green fluorescence protein (GFP) was generated. Polyepitope transduced EBV-LCL could be isolated on… CONTINUE READING
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