Enrichment of Prostate Cancer Stem-Like Cells from Human Prostate Cancer Cell Lines by Culture in Serum-Free Medium and Chemoradiotherapy

@inproceedings{Wang2013EnrichmentOP,
  title={Enrichment of Prostate Cancer Stem-Like Cells from Human Prostate Cancer Cell Lines by Culture in Serum-Free Medium and Chemoradiotherapy},
  author={Lei Wang and Xing Huang and Xinmin Zheng and Xinghuan Wang and Shiwen Li and Lin Zhang and Zhonghua Yang and Zhiping Xia},
  booktitle={International journal of biological sciences},
  year={2013}
}
The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonly used human prostate cancer (PCa) cell lines (DU145, PC-3 and LNCaP) were examined for their expression of the putative stem cell markers CD133 and CD44 via flow cytometric… CONTINUE READING

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