Enrichment and enumeration of circulating tumor cells by efficient depletion of leukocyte fractions.

@article{Wu2014EnrichmentAE,
  title={Enrichment and enumeration of circulating tumor cells by efficient depletion of leukocyte fractions.},
  author={Shiyang Wu and Zhiming Liu and Suyan Liu and Li Lin and Weiwei Yang and Jiasen Xu},
  journal={Clinical chemistry and laboratory medicine},
  year={2014},
  volume={52 2},
  pages={243-51}
}
BACKGROUND Enumeration and characterization of circulating tumor cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, CTCs are rare, making their isolation a major technological challenge. We developed a technique for enrichment, and subsequent characterization of CTCs based on efficient depletion of human leukocytes. METHODS The technique (CanPatrolTM CTC enrichment) we developed is based on red blood cell lysis to remove erythrocytes, followed by… CONTINUE READING
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