Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5.

@article{Song2017EnrichingTH,
  title={Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5.},
  author={Yanfang Song and Yu Unn Gan and Qing Wang and Zihong Meng and Guohua Li and Yuling Shen and Yufeng Wu and Peiying Li and Ming Yao and Jianren Gu and Hong Tu},
  journal={Cancer research},
  year={2017},
  volume={77 7},
  pages={1611-1622}
}
Mice housed in an enriched environment display a tumor-resistant phenotype due to eustress stimulation. However, the mechanisms underlying enriched environment-induced protection against cancers remain largely unexplained. In this study, we observed a significant antitumor effect induced by enriched environment in murine pancreatic cancer and lung cancer models. This effect remained intact in T/B lymphocyte-deficient Rag1-/- mice, but was nearly eliminated in natural killer (NK) cell-deficient… CONTINUE READING