Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis

@inproceedings{Chen2017EnrichedHP,
  title={Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis},
  author={Jia-yi Chen and Yuan Yu and Y. J. Yuan and Yu-jing Zhang and Xue-Peng Fan and Shi-Ying Yuan and Jian-cheng Zhang and Shang-long Yao},
  booktitle={Cell Death Discovery},
  year={2017}
}
Enriched environment (EE) is shown to promote angiogenesis, neurogenesis and functional recovery after ischemic stroke. However, the underlying mechanisms remain unclear. C57BL/6 mice underwent middle cerebral artery occlusion (60 min) followed by reperfusion, after which mice were housed in either standard environment (SE) or EE. Here we found that post-ischemic EE exhibited decreased depression and anxiety-like behavior, and promoted angiogenesis and functional recovery compared to SE mice… CONTINUE READING

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