Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats

@article{Veena2009EnrichedER,
  title={Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats},
  author={Jayagopalan Veena and Bettadapura N. Srikumar and K. Mahati and V. Bhagya and Trichur R. Raju and Byrathnahalli S Shankaranarayana Rao},
  journal={Journal of Neuroscience Research},
  year={2009},
  volume={87}
}
Adult neurogenesis, particularly in the subgranular zone, is thought to be linked with learning and memory. Chronic stress inhibits adult hippocampal neurogenesis and also impairs learning and memory. On the other hand, exposure to enriched environment (EE) is reported to enhance the survival of new neurons and improve cognition. Accordingly, in the present study, we examined whether short‐term EE after stress could ameliorate the stress‐induced decrease in hippocampal cell proliferation and… 
Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits
TLDR
Exposure to EE can bring out positive effects on synaptic plasticity in the hippocampus and thereby elicit its beneficial effects on cognitive functions, as explored in this study.
Enriched environment induces beneficial effects on memory deficits and microglial activation in the hippocampus of type 1 diabetic rats
TLDR
EE was shown to help to ameliorate cognitive comorbidities associated with T1DM, possibly by reducing hyperactivity in the hypothalamic–pituitary–adrenal axis and microglial activation in diabetic animals.
Enriched Environment Minimizes Anxiety/Depressive-Like Behavior in Rats Exposed to Immobilization Stress and Augments Hippocampal Neurogenesis (In Vitro).
TLDR
The data highlight the positive impact of EE against stress-related behavioral changes in rats exposed to chronic immobilization stress perhaps by interfering with the differentiation of neurospheres and neurogenesis.
Beneficial effects of environmental enrichment on behavior, stress reactivity and synaptophysin/BDNF expression in hippocampus following early life stress
INFLUENCE OF ENVIRONMENTAL ENRICHMENT EXPOSURE ON COGNITIVE PERFORMANCE AND NEUROPROTECTION OF DIABETIC , STRESSED RAT DENTATE GYRUS AND AMYGDALA
TLDR
Enriched cage housing significantly improved the cognitive abilities and decreased the amount of neuronal damage caused by diabetes and stress in diabetic and stressed rats.
Oxotremorine treatment restores hippocampal neurogenesis and ameliorates depression-like behaviour in chronically stressed rats
TLDR
The results indicate that the restoration of impaired neurogenesis and hippocampal volume could be associated with the behavioural recovery by oxotremorine, and imply the muscarinic regulation of adult neuroGenesis and incite the potential utility of cholinomimetics in ameliorating cognitive dysfunction in stress-related disorders.
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