Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis.

@article{Bonagura1994EnrichedHP,
  title={Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis.},
  author={Vincent R Bonagura and Frederick P. Siegal and Allan L. Abramson and Frances Santiago-Schwarz and Marianne O'Reilly and Kalpit Shah and D J Drake and Bettie M. Steinberg},
  journal={Clinical and diagnostic laboratory immunology},
  year={1994},
  volume={1 3},
  pages={357-60}
}
Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate… CONTINUE READING

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