Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression

  title={Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression},
  author={Dan Fan and Jun Li and Bin Zheng and Lei Hua and Zhiyi Zuo},
  journal={Molecular Neurobiology},
  • D. Fan, Jun Li, Z. Zuo
  • Published 2014
  • Biology, Psychology, Medicine
  • Molecular Neurobiology
Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neurogenesis contributes to cognition. It is known that enriched environment (EE) enhances neurogenesis. We determined whether EE attenuated surgery-induced cognitive impairment and whether growth factors and neurogenesis played a role in the EE effect. Eight-week-old C57BL/6J mice were subjected to carotid artery exposure. Their learning and memory were assessed by Barnes maze, and fear conditioning started 2 weeks… 
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