Enolase as a plasminogen binding protein in Leishmania mexicana

  title={Enolase as a plasminogen binding protein in Leishmania mexicana},
  author={Gilmer Vanegas and Wilfredo Qui{\~n}ones and C{\'e}sar Carrasco-L{\'o}pez and Juan Lu{\'i}s Concepci{\'o}n and Fernando Albericio and Luisana Avil{\'a}n},
  journal={Parasitology Research},
Enolase is a glycolytic and gluconeogenic enzyme also found on the surface of several eukaryotic and prokaryotic cells where it acts as plasminogen binding protein. Leishmania mexicana, one of the causative agents of Leishmaniasis, binds plasminogen and, in this parasite, enolase has been previously found associated with the external face of the plasma membrane. In this work, we show that the purified recombinant enolase has plasminogen binding activity indicating that, at the surface of the… CONTINUE READING

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