Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer

@inproceedings{Qian2017Enolase1S,
  title={Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer},
  author={Xiaoling Qian and Wenxia Xu and Jinye Xu and Qiqi Shi and Jiaqiu Li and Yu Chun Weng and Zhi-nong Jiang and Lifeng Feng and Xian Wang and Jianwei Zhou and Hong Chuan Jin},
  booktitle={Oncotarget},
  year={2017}
}
Chemotherapy is the major choice for the cancer treatment of early and advanced stages. However, intrinsic or acquired drug resistance significantly restricts the clinical efficacy of chemotherapy. It is critical to develop novel approaches to detect and overcome drug resistance. In this study, we demonstrated that accelerated glycolysis played a pivotal role in both intrinsic and acquired cisplatin-resistance of gastric cancer cells. The metabolic reprogramming of cisplatin-resistant cells was… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Granulin A Synergizes with Cisplatin to Inhibit the Growth of Human Hepatocellular Carcinoma

  • International journal of molecular sciences
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES

Effects of α-enolase (ENO1) over-expression on malignant biological behaviors of AGS cells.

  • International journal of clinical and experimental medicine
  • 2015
VIEW 1 EXCERPT