Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

@article{Bilsky2000EnkephalinGA,
  title={Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.},
  author={Edward J. Bilsky and Richard D. Egleton and Scott A. Mitchell and Michael M. Palian and P. A. Davis and John D. Huber and Honor Jones and Henry I. Yamamura and Jaqueline Janders and Thomas P Davis and Frank Porreca and Victor J. Hruby and Robin Polt},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 13},
  pages={
          2586-90
        }
}
Endogenous peptides (e.g. enkephalins) control many aspects of brain function, cognition, and perception. The use of these neuroactive peptides in diverse studies has led to an increased understanding of brain function. Unfortunately, the use of brain-derived peptides as pharmaceutical agents to alter brain chemistry in vivo has lagged because peptides do not readily penetrate the blood-brain barrier. Attachment of simple sugars to enkephalins increases their penetration of the blood-brain… CONTINUE READING

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