Enkephalin-degrading dipeptidylaminopeptidase: characterization of the active site and selective inhibition.

Abstract

The enkephalins are degraded in vitro by three types of metallopeptidases including a dipeptidylaminopeptidase (DAP) which releases Tyr-Gly. In order to test the physiological significance of this enzyme in enkephalin metabolism, a membrane-bound DAP from porcine brain was purified. The structural characteristics of the active site of this enzyme were… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.