Enkephalin-degrading dipeptidylaminopeptidase: characterization of the active site and selective inhibition.


The enkephalins are degraded in vitro by three types of metallopeptidases including a dipeptidylaminopeptidase (DAP) which releases Tyr-Gly. In order to test the physiological significance of this enzyme in enkephalin metabolism, a membrane-bound DAP from porcine brain was purified. The structural characteristics of the active site of this enzyme were… (More)


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