Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.

@article{Kalivas1983EnkephalinAO,
  title={Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.},
  author={P W Kalivas and Erik Widerl{\"o}v and David Stanley and George R. Breese and Arthur J. Prange},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1983},
  volume={227 1},
  pages={229-37}
}
Enkephalin has been identified by immunohistochemistry to be present in the vicinity of mesolimbic dopaminergic perikarya in the ventral tegmental area and axonal terminals in the nucleus accumbens. To evaluate the possibility that endogenous enkephalin may physiologically modulate the mesolimbic dopamine (DA) system, the effect of microinjection of the peptidase-resistant enkephalin analog, D-Ala2-Met5-enkephalinamide (DALA), in the ventral tegmental area and nucleus accumbens was examined… CONTINUE READING
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