Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.

@article{Binley2002EnhancingTP,
  title={Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins.},
  author={James M Binley and Rogier W. Sanders and Aditi S Master and Charmagne S Cayanan and Cheryl L Wiley and Linnea A Schiffner and Bruce Travis and Shawn E. Kuhmann and Dennis R. Burton and Shiu-Lok Hu and William C. Olson and John P. Moore},
  journal={Journal of virology},
  year={2002},
  volume={76 6},
  pages={2606-16}
}
In virus-infected cells, the envelope glycoprotein (Env) precursor, gp160, of human immunodeficiency virus type 1 is cleaved by cellular proteases into a fusion-competent gp120-gp41 heterodimer in which the two subunits are noncovalently associated. However, cleavage can be inefficient when recombinant Env is expressed at high levels, either as a full… CONTINUE READING