Enhancing the osteogenic efficacy of human bone marrow aspirate: concentrating osteoprogenitors using wave-assisted filtration.

@article{Dawson2013EnhancingTO,
  title={Enhancing the osteogenic efficacy of human bone marrow aspirate: concentrating osteoprogenitors using wave-assisted filtration.},
  author={Jonathan I Dawson and James Oliver Smith and Alexander Aarvold and Jonathan N Ridgway and Steven J Curran and Douglas G. Dunlop and Richard O C Oreffo},
  journal={Cytotherapy},
  year={2013},
  volume={15 2},
  pages={242-52}
}
BACKGROUND Recent approaches have sought to harness the potential of stem cells to regenerate bone that is lost as a consequence of trauma or disease. Bone marrow aspirate (BMA) provides an autologous source of osteoprogenitors for such applications. However, previous studies indicated that the concentration of osteoprogenitors present in BMA is less than required for robust bone regeneration. We provide further evidence for the importance of BMA enrichment for skeletal tissue engineering… CONTINUE READING
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