Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro.

@article{Berger2015EnhancingTF,
  title={Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro.},
  author={Dustin R Berger and Brenton R. Ware and Matthew D. Davidson and Samuel R Allsup and Salman R Khetani},
  journal={Hepatology},
  year={2015},
  volume={61 4},
  pages={1370-81}
}
UNLABELLED Induced pluripotent stem cell-derived human hepatocyte-like cells (iHeps) could provide a powerful tool for studying the mechanisms underlying human liver development and disease, testing the efficacy and safety of pharmaceuticals across different patients (i.e., personalized medicine), and enabling cell-based therapies in the clinic. However, current in vitro protocols that rely upon growth factors and extracellular matrices (ECMs) alone yield iHeps with low levels of liver… CONTINUE READING
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