Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization).

@article{Rabussay2002EnhancingTE,
  title={Enhancing the effectiveness of drug-based cancer therapy by electroporation (electropermeabilization).},
  author={Dietmar P. Rabussay and Gurvinder S. Nanda and Paul M. Goldfarb},
  journal={Technology in cancer research & treatment},
  year={2002},
  volume={1 1},
  pages={71-82}
}
Many conventional chemotherapeutic drugs, as well as DNA for cancer gene therapy, require efficient access to the cell interior to be effective. The cell membrane is a formidable barrier to many of these drugs, including therapeutic DNA constructs. Electropermeabilization (EP, often used synonymously with "electroporation") has become a useful method to temporarily increase the permeability of the cell membrane, allowing a broad variety of molecules efficient access to the cell interior. EP is… CONTINUE READING