Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization.

@article{Mooso2012EnhancingTE,
  title={Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization.},
  author={Benjamin A. Mooso and Ruth L Vinall and Clifford G Tepper and Rosalinda M Savoy and Jean P Cheung and Sheetal Singh and Salma Siddiqui and Yu Wang and Roble G. Bedolla and Anthony Martinez and Maria M Mudryj and H Kung and Ralph W. deVere White and Paramita M. Ghosh},
  journal={Endocrine-related cancer},
  year={2012},
  volume={19 6},
  pages={759-77}
}
As prostate cancer (CaP) is regulated by androgen receptor (AR) activity, metastatic CaP is treated with androgen deprivation therapy (ADT). Despite initial response, patients on ADT eventually progress to castration-resistant CaP (CRPC), which is currently incurable. We previously showed that cleavage of the 280 kDa structural protein Filamin A (FlnA) to a 90 kDa fragment, and nuclear localization of the cleaved product, sensitized CRPC cells to ADT. Hence, treatment promoting FlnA nuclear… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Filamin A: Insights into its Exact Role in Cancers

Pathology & Oncology Research • 2015
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 74 references

Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 3 Excerpts
Highly Influenced

Effects of a genistein - rich extract on PSA levels in men with a history of prostate cancer

RW White, A Tsodikov, +3 authors RM Hackman
Urology • 2010
View 3 Excerpts
Highly Influenced

Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…