Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine (‘ecstasy’) through iterative chemical redesign: mechanisms and pathways to cell death

@article{Wasik2011EnhancingTA,
  title={Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine (‘ecstasy’) through iterative chemical redesign: mechanisms and pathways to cell death},
  author={A. M. Wasik and Michael N. Gandy and M. McIldowie and M. Holder and A. Chamba and A. Challa and Katie D. Lewis and S. Young and D. Scheel-Toellner and M. Dyer and N. Barnes and M. Piggott and J. Gordon},
  journal={Investigational New Drugs},
  year={2011},
  volume={30},
  pages={1471-1483}
}
SummaryWhile 3,4-methylenedioxymethamphetamine (MDMA/‘ecstasy’) is cytostatic towards lymphoma cells in vitro, the concentrations required militate against its translation directly to a therapeutic in vivo. The possibility of ‘redesigning the designer drug’, separating desired anti-lymphoma activity from unwanted psychoactivity and neurotoxicity, was therefore mooted. From an initial analysis of MDMA analogues synthesized with a modified α-substituent, it was found that incorporating a phenyl… Expand
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