Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment.

@article{Sukumaran2018EnhancingTP,
  title={Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment.},
  author={Sujita Sukumaran and Norihiro Watanabe and Pradip Bajgain and K Raja and Somala Mohammed and William E. Fisher and Malcolm K. Brenner and Ann M. Leen and Juan A. Fuentes Vera},
  journal={Cancer discovery},
  year={2018},
  volume={8 8},
  pages={
          972-987
        }
}
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells has produced tumor responses even in patients with refractory diseases. However, the paucity of antigens that are tumor selective has resulted, on occasion, in "on-target, off-tumor" toxicities. To address this issue, we developed an approach to render T cells responsive to an expression pattern present exclusively at the tumor by using a trio of novel chimeric receptors. Using pancreatic cancer as a model, we demonstrate… CONTINUE READING