Enhancing radiotherapy by lipid nanocapsule-mediated delivery of amphiphilic gold nanoparticles to intracellular membranes.

@article{Yang2014EnhancingRB,
  title={Enhancing radiotherapy by lipid nanocapsule-mediated delivery of amphiphilic gold nanoparticles to intracellular membranes.},
  author={Yu-Sang Sabrina Yang and Randy P Carney and Francesco Stellacci and Darrell J Irvine},
  journal={ACS nano},
  year={2014},
  volume={8 9},
  pages={8992-9002}
}
Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Here we describe a strategy using crosslink-stabilized lipid nanocapsules (NCs) as carriers to transport such membrane-penetrating particles into tumor cells and promote their transfer to intracellular membranes for enhanced radiotherapy of cancer. We synthesized and characterized interbilayer-crosslinked… CONTINUE READING

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