Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells.

@article{Thomas2002EnhancingPD,
  title={Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells.},
  author={Mini P. Thomas and Alexander M. Klibanov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 23},
  pages={
          14640-5
        }
}
The effect of various chemical modifications of nitrogen atoms on the efficiency of polyethylenimines (PEIs) as synthetic vectors for the delivery of plasmid DNA into monkey kidney cells in vitro has been systematically investigated. The resultant structure-activity relationship has both provided mechanistic insights and led to PEI derivatives with markedly enhanced performance. For example, N-acylation of PEI with the molecular mass of 25 kDa (PEI25, one of the most potent polycationic gene… CONTINUE READING

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