Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

@article{Tufi2014EnhancingNM,
  title={Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease},
  author={Roberta Tufi and Sonia Gandhi and In{\^e}s P. de Castro and Susann Lehmann and Plamena R. Angelova and David Dinsdale and Emma Deas and Helene Plun-Favreau and Pierluigi Nicotera and Andrey Y Abramov and Anne E. Willis and Giovanna R Mallucci and Samantha Hui Yong Loh and L Miguel Martins},
  journal={Nature Cell Biology},
  year={2014},
  volume={16},
  pages={157-166}
}
Mutations in PINK1 cause early-onset Parkinson’s disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1 as a central mechanism of PD pathogenesis. Here we show that global analysis of transcriptional changes in Drosophila pink1 mutants reveals an upregulation of genes involved in nucleotide metabolism, critical for neuronal mitochondrial DNA synthesis. These key transcriptional changes were also detected in brains of PD patients harbouring… CONTINUE READING
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References

Publications referenced by this paper.
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Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

I Pimenta de Castro
Cell Death Differ • 2012

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.

Proceedings of the National Academy of Sciences of the United States of America • 2010

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