Enhancing gene targeting with designed zinc finger nucleases.

@article{Bibikova2003EnhancingGT,
  title={Enhancing gene targeting with designed zinc finger nucleases.},
  author={Marina Bibikova and Kelly J. Beumer and Jonathan K. Trautman and Dana Carroll},
  journal={Science},
  year={2003},
  volume={300 5620},
  pages={764}
}
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique (1). A general method for improving the efficiency of gene targeting would be valuable in many circumstances, as would the extension of this genetic tool to a broader range of organisms. Model experiments have demonstrated that a… CONTINUE READING