Enhancing factor protein from mouse small intestines belongs to the phospholipase A2 family

@article{Mulherkar1993EnhancingFP,
  title={Enhancing factor protein from mouse small intestines belongs to the phospholipase A2 family},
  author={Rita Mulherkar and R. S. Rao and L Rao and Varsha Patki and Virander S. Chauhan and Madhav G. Deo},
  journal={FEBS Letters},
  year={1993},
  volume={317}
}
Expression of enhancing factor/phospholipase A2 in ICRC mice
TLDR
The molecular characterization of the ICRC mouse with respect to the enhancing factor gene is reported, demonstrating that EF from Balb/c and ICRC intestines are either immunologically identical or closely related to each other although, quantitatively, EF was very low in ICRC mice.
Trace amounts of enhancing factor/phospholipase A2 in mouse peritoneal exudate cells
TLDR
The presence of trace amounts of EF in the peritoneal exudate cells could be a unique mode of transport of growth factor modulator to the site of injury to aid in regeneration/cell proliferation of damaged tissue.
Comparison of the activities of wild type and mutant enhancing factor/mouse secretory phospholipase A2 proteins
TLDR
Deletion mutation analysis of EF cDNA carried out in the laboratory showed that enhancing activity and phospholipase activity are two separate activities that reside in the same molecule.
Heparin inhibits enhancing factor/phospholipase A2 activity and its binding to the cell surface
TLDR
Inhibition of binding of EF to cells byHeparin indicates that heparin binding region forms at least part of the receptor binding domain, which suggests that the receptor for EF on the cell surface could be a heparIn sulphate proteoglycan.
A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains (*)
TLDR
The identification of this mutation should not only help define the physiological role of sPLA2 but also has important implications in mouse inflammatory models developed by targeted mutagenesis.
The Human 180-kDa Receptor for Secretory Phospholipases A2
TLDR
The molecular cloning and expression of one of these sPLA2receptors from human kidney is reported, with results indicating a 1.6:1 ratio between the levels of transcripts encoding for the membrane-bound and soluble forms of the receptor, respectively.
Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.
TLDR
Results indicate that the mouse M-type receptor is selective for only a subset of mouse sPLA2s from the group I/II/V/X structural collection.
Bactericidal properties of murine intestinal phospholipase A2.
TLDR
Findings identify iPLA2 as part of the antimicrobial arsenal that equips Paneth cells to protect the small intestinal crypts from microbial invasion and this enzyme may also contribute to antibacterial defenses elsewhere in the body.
Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes.
TLDR
Keratinocytes express several forms of phospholipase A2 that differ in their substrate specificities and mechanisms of activation, resulting in distinct agonist-specific fatty acid release profiles.
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TLDR
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