Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture.

Abstract

Hand, foot and mouth diseases (HFMD) are mainly caused by Enterovirus A71 (EV-A71) infections. Clinical trials in Asia conducted with formalin-inactivated EV-A71 vaccine candidates produced from serum-free Vero cell culture using either roller bottle or cell factory technology, are found to be safe and highly efficacious. To increase vaccine yields and… (More)
DOI: 10.1016/j.vaccine.2017.02.042

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