Enhancing effect of serum ultrafiltrate on the activity of cephalosporins against gram-negative bacilli.

@article{Leggett1989EnhancingEO,
  title={Enhancing effect of serum ultrafiltrate on the activity of cephalosporins against gram-negative bacilli.},
  author={James E. Leggett and William Allan Craig},
  journal={Antimicrobial agents and chemotherapy},
  year={1989},
  volume={33 1},
  pages={
          35-40
        }
}
A few studies have suggested that the inhibitory effect of serum on activity of broad-spectrum cephalosporins is less than that predicted by the degree of protein binding. Microdilution MICs of ceftriaxone, cefoperazone, moxalactam, and ceftizoxime were therefore determined against ATCC and clinical strains of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus in Mueller-Hinton broth containing either human albumin (as 0, 2.5, or 5% solution) or heat… CONTINUE READING

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