Enhancing effect of cetyl lactate on the percutaneous absorption of indomethacin in rats.

@article{Kaiho1989EnhancingEO,
  title={Enhancing effect of cetyl lactate on the percutaneous absorption of indomethacin in rats.},
  author={Fusao Kaiho and Ryoji Koike and Hiroshi Nomura and Hideki Hara and Kuniaki Maruoka and Masahiro Dohi and Y Kato},
  journal={Chemical \& pharmaceutical bulletin},
  year={1989},
  volume={37 4},
  pages={
          1114-6
        }
}
The enhancing effect of cetyl lactate (CL) on the percutaneous absorption of indomethacin (ID) from test solutions in propylene glycol (PG) was investigated by using the abdominal skin of rats in vivo. The percutaneous absorption rate of ID from 1 or 3% CL-PG test solution through the intact skin of rats was observed to be faster than that from the control solution (without CL). The bioavailability of ID was about 0.04% for the control solution, 2.2% for 1% CL-PG and 6.8% for 3% CL-PG test… 
Enhancing effect of alpha-monoisostearyl glyceryl ether on the percutaneous penetration of indomethacin through excised rat skin.
TLDR
It is suggested that GE-IS acts directly on the stratum corneum and alters the permeability of the skin and therefore functions as a penetration enhancer of IM through rat skin.
In vitro Enhancement of Lactate Esters on the Percutaneous Penetration of Drugs with Different Lipophilicity
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Investigation of the effect of a series of lactate esters as penetration enhancers on the in vitro skin permeation of four drugs with different physicochemical properties suggested that they may be more efficient at enhancing the penetration of hydrophilic drugs than lipophilic drugs.
Transdermal Delivery and Accumulation of Indomethacin in Subcutaneous Tissues in Rats
TLDR
The effects of a novel topical penetration enhancer for lipophilic compounds, a trans‐phase delivery system (TPDS), a solution of benzyl alcohol, iso‐propanol and acetone, on the distribution of indomethacin in various tissues locally and remote from the site of application are studied.
α‐Monoisostearyl glyceryl ether enhances percutaneous penetration of indometacin in‐vivo
TLDR
GE‐IS enhances penetration in‐vivo and improves the anti‐inflammatory effects of indometacin in animal models, which might contribute to the development of cosmetic or medical formulations to improve transfer of bioactive substances to hypodermal sites.
An insight on human skin penetration of diflunisal: lipogel versus hydrogel microemulsion
TLDR
The elaborated lecithin organogels are potential carriers that create a good opportunity for transdermal delivery of diflunisal overcoming the side effects associating its oral route.
Delivery of Erythromycin to Subcutaneous Tissues in Rats by Means of a Trans‐phase Delivery System
  • L. PengM. Nimni
  • Medicine, Biology
    The Journal of pharmacy and pharmacology
  • 1999
TLDR
A trans‐phase delivery system (TPDS), a mixture of benzyl alcohol, acetone and isopropanol, has been shown to enhance the effective transport of the antibiotic erythromycin across the epidermal barrier and enhance accumulation in the dermis.
Esters of Mono‐ and Alkenyl Carboxylic Acids and Mono‐ and Polyalcohols
This volume contains three chapters reviewing 12 classes of organic compounds called esters. This chapter (Chapter 57) reviews esters of monocarboxylic acids and mono- and polyalcohols and
Esters of Mono‐ and Alkenyl Carboxylic Acids and Mono‐ and Polyalcohols
This volume contains three chapters reviewing 12 classes of the organic compounds called esters. Chapter 79, this chapter, reviews (1) esters of monocarboxylic acids and mono- and polyalcohols and