Enhancing cellular immune response to HBV M DNA vaccine in mice by codelivery of interleukin-18 recombinant.

@article{Chen2004EnhancingCI,
  title={Enhancing cellular immune response to HBV M DNA vaccine in mice by codelivery of interleukin-18 recombinant.},
  author={Jianzhong Chen and Haihong Henry Zhu and Ke-zhou Liu and Zhi Chen},
  journal={Journal of Zhejiang University. Science},
  year={2004},
  volume={5 4},
  pages={467-71}
}
OBJECTIVE To investigate the effect of interleukin-18 (IL-18) on immune response induced by plasmid encoding hepatitis B virus middle protein antigen and to explore new strategies for prophylactic and therapeutic HBV DNA vaccines. METHODS BALB/c mice were immunized with pCMV-M alone or co-immunized with pcDNA3-18 and pCMV-M and then their sera were… CONTINUE READING