Enhancing and targeting nucleic acid delivery by magnetic force

  title={Enhancing and targeting nucleic acid delivery by magnetic force},
  author={Christian Plank and Martina Anton and Carsten Rudolph and Joseph Rosenecker and Florian Kr{\"o}tz},
  journal={Expert Opinion on Biological Therapy},
  pages={745 - 758}
Insufficient contact of inherently highly active nucleic acid delivery systems with target cells is a primary reason for their often observed limited efficacy. Physical methods of targeting can overcome this limitation and reduce the risk of undesired side effects due to non-target site delivery. The authors and others have developed a novel means of physical targeting, exploiting magnetic force acting on nucleic acid vectors associated with magnetic particles in order to mediate the rapid… 

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