Enhancing M Currents: A Way Out for Neuropathic Pain?

  title={Enhancing M Currents: A Way Out for Neuropathic Pain?},
  author={Ivan Rivera-Arconada and Carolina Roza and Jose A Lopez-Garcia},
  booktitle={Front. Mol. Neurosci.},
Almost three decades ago, the M current was identified and characterized in frog sympathetic neurons (Brown and Adams, 1980). The years following this discovery have seen a huge progress in the understanding of the function and the pharmacology of this current as well as on the structure of the underlying ion channels. Therapies for a number of syndromes involving abnormal levels of excitability in neurons are benefiting from research on M currents. At present, the potential of M current… CONTINUE READING

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Activation of pre - synaptic M - type K + channels inhibits [ 3 H ] Daspartate release by reducing Ca 2 + entry through P / Qtype voltage - gated Ca 2 + channels

  • R. Luisi, E. Panza, +7 authors M. Taglialatela
  • J . Neurochem .
  • 2009
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