Enhancing HMM-based protein profile-profile alignment with structural features and evolutionary coupling information

@inproceedings{Deng2014EnhancingHP,
  title={Enhancing HMM-based protein profile-profile alignment with structural features and evolutionary coupling information},
  author={Xin Deng and Jianlin Cheng},
  booktitle={BMC Bioinformatics},
  year={2014}
}
Protein sequence profile-profile alignment is an important approach to recognizing remote homologs and generating accurate pairwise alignments. It plays an important role in protein sequence database search, protein structure prediction, protein function prediction, and phylogenetic analysis. In this work, we integrate predicted solvent accessibility… CONTINUE READING