Several studies have demonstrated that small effects observed in psi experiments can be enhanced through the application of statistical averaging procedures such as majority vote. In one such study, a technique known as sequential analysis was used to increase the effective hit rate in a pseudorandom number generator experiment. Sequential analysis is an attractive alternative to the more common fixed length procedure because it provides greater statistical power with fewer trials. The present study was a conceptual replication of the use of sequential analysis in a psi experiment, with the addition of a novel bit-weighting scheme designed to further enhance the obtained hit rate. The experiment, consisting of five blocks of 1,000 sequential analysis trials each, produced by a single subject, showed evidence for psi and replicated the finding that statistical averaging techniques can be used to enhance the “raw” hit rate. The results also suggested that the use of a bit weighting scheme in conjunction with sequential analysis may be a promising area to explore in further amplifying hit rates in similar experiments.