Enhancing Chemotherapy Response with Bmi-1 Silencing in Ovarian Cancer

  title={Enhancing Chemotherapy Response with Bmi-1 Silencing in Ovarian
  author={Enfeng Wang and Sanjib Bhattacharyya and Annam{\'a}ria Szabolcs and Cristian Rodriguez-Aguayo and Nicholas B. Jennings and Gabriel L{\'o}pez-Berestein and Priyabrata Mukherjee and Anil Sood and Resham Bhattacharya},
  booktitle={PloS one},
Undoubtedly ovarian cancer is a vexing, incurable disease for patients with recurrent cancer and therapeutic options are limited. Although the polycomb group gene, Bmi-1 that regulates the self-renewal of normal stem and progenitor cells has been implicated in the pathogenesis of many human malignancies, yet a role for Bmi-1 in influencing chemotherapy response has not been addressed before. Here we demonstrate that silencing Bmi-1 reduces intracellular GSH levels and thereby sensitizes… CONTINUE READING
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