Enhancing CD8 T-cell memory by modulating fatty acid metabolism

  title={Enhancing CD8 T-cell memory by modulating fatty acid metabolism},
  author={Erika L Pearce and Matthew Cunningham Walsh and Pedro J. Cejas and Gretchen M. Harms and Hao Shen and Li-San Wang and Russell G. Jones and Yongwon Choi},
CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen stimulation undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific effector (TE) populations, followed by the persistence of long-lived memory (TM) cells. Although this predictable pattern of CD8 T-cell responses is well established, the underlying cellular mechanisms regulating the transition… CONTINUE READING
Highly Influential
This paper has highly influenced 30 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
452 Citations
45 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 452 extracted citations


Publications referenced by this paper.
Showing 1-10 of 45 references

signal transduction fuels T cell activation

  • R. G. Jones, Thompson, C. B. Revving the engine
  • Immunity 27, 173–178
  • 2007

Similar Papers

Loading similar papers…