Enhancing CD8 T-cell memory by modulating fatty acid metabolism

@article{Pearce2009EnhancingCT,
  title={Enhancing CD8 T-cell memory by modulating fatty acid metabolism},
  author={Erika L Pearce and Matthew Cunningham Walsh and Pedro J. Cejas and Gretchen M. Harms and Hao Shen and Li-San Wang and Russell G. Jones and Yongwon Choi},
  journal={Nature},
  year={2009},
  volume={460},
  pages={103-107}
}
CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in constant numbers, but on antigen stimulation undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific effector (TE) populations, followed by the persistence of long-lived memory (TM) cells. Although this predictable pattern of CD8 T-cell responses is well established, the underlying cellular mechanisms regulating the transition… CONTINUE READING
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