Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.

@article{Zhang2016EnhancingBA,
  title={Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.},
  author={Limin Zhang and Luan Cen and Shaogang Qu and Lei Wei and Mingshu Mo and Junmin Feng and Congcong M. Sun and Yousheng Xiao and Qin Luo and Shaomin Li and Xinling Yang and Pingyi Xu},
  journal={PloS one},
  year={2016},
  volume={11 4},
  pages={
          e0152931
        }
}
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3β antagonists LiCl and SB216763 were used to activate Wnt/β-catenin pathway experimentally. However, the detail mechanism underlying the neuroprotection against… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Similar Papers

Loading similar papers…