Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression.

@article{Iyer2010EnhancersOG,
  title={Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression.},
  author={Anita Iyer and Nichol L. G. Miller and Kathleen Yip and Brian A. Tran and Pamela L Mellon},
  journal={Molecular endocrinology},
  year={2010},
  volume={24 10},
  pages={1949-64}
}
GnRH, the central regulator of reproductive function, is produced by only approximately 800 highly specialized hypothalamic neurons. Previous studies identified a minimal promoter [GnRH minimal promoter (GnRH-P)] (-173/+1) and a neuron-specific enhancer [GnRH-enhancer (E)1] (-1863/-1571) as regulatory regions in the rat gene that confer this stringent specificity of GnRH expression to differentiated GnRH neurons. In transgenic mice, these two elements target only GnRH neurons but fail to drive… CONTINUE READING
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moter sequences targeting tissue - specific gene expression of hypothalamic and ovarian gonadotropin - releasing hormone in vivo

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