Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain

@inproceedings{Schultz2015EnhancersCW,
  title={Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain},
  author={Bryant M. Schultz and Gwendolyn A. Gallicio and Matteo Cesaroni and Lena N. Lupey and Nora Engel},
  booktitle={Nucleic acids research},
  year={2015}
}
The imprinted Kcnq1 domain contains a differentially methylated region (KvDMR) in intron 11 of Kcnq1. The Kcnq1ot1 non-coding RNA emerges from the unmethylated paternal KvDMR in antisense direction, resulting in cis-repression of neighboring genes. The KvDMR encompasses the Kcnq1ot1 promoter, CTCF sites and other DNA elements, whose individual contribution to regulation of the endogenous domain is unknown. We find that paternal inheritance of a deletion of the minimal Kcnq1ot1 promoter… CONTINUE READING
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