Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.

Abstract

The intracellular RIG-I-like receptors recognize 5'-triphosphate viral genomic RNA and initiate the production of cytokines through mitochondria adaptor VISA. The regulation of this signal pathway is largely unknown. In this study, we report that the histone methyltransferase enhancer of zeste homolog 2 (EZH2) inhibits RIG-I signal pathway in an… (More)
DOI: 10.4049/jimmunol.1203143

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