Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.

@article{Kee2007EnhancerOP,
  title={Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.},
  author={Hae Jin Kee and Ju-Ryoung Kim and Kwang-Il Nam and Hyun Young Park and Sera Shin and Jeong Chul Kim and Yohei Shimono and Masahide Takahashi and Myung Ho Jeong and Nacksung Kim and Kyung Keun Kim and Hyun Kook},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 10},
  pages={7700-9}
}
Homeodomain only protein, Hop, is an unusual small protein that modulates target gene transcription without direct binding to DNA. Here we show that Hop interacts with Enhancer of Polycomb1 (Epc1), a homolog of a Drosophila polycomb group gene product that regulates transcription, to induce the skeletal muscle differentiation. Yeast two-hybrid assay with the human adult heart cDNA library revealed that Hop can associate with Epc1. The amino-terminal domain of Epc1 as well as full Epc1… CONTINUE READING

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