Enhancer of human polyoma JC virus contains nuclear factor I-binding sequences; analysis using mouse brain nuclear extracts.

@article{Tamura1988EnhancerOH,
  title={Enhancer of human polyoma JC virus contains nuclear factor I-binding sequences; analysis using mouse brain nuclear extracts.},
  author={Toru Tamura and Toshiaki Inoue and Kazuhiro Nagata and Katsuhiko Mikoshiba},
  journal={Biochemical and biophysical research communications},
  year={1988},
  volume={157 2},
  pages={419-25}
}
Neurotrophic human JC virus carries a 98 bp duplicate enhancer responsible for tissue-specific gene expression. DNase I footprinting studies using mouse brain nuclear extracts revealed weak (pseudo NFI motif) and strong (NFI motif) nuclear factor I-binding sequences just upstream (at 229) and in the middle (at 156 and 58) of the enhancer, respectively. In vitro transcription driven in brain extracts demonstrated that the NFI motif is a possible transcription control element. Together with… CONTINUE READING
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