Enhancer function: mechanistic and genome-wide insights come together.

@article{Plank2014EnhancerFM,
  title={Enhancer function: mechanistic and genome-wide insights come together.},
  author={Jennifer L. Plank and Ann Dean},
  journal={Molecular cell},
  year={2014},
  volume={55 1},
  pages={5-14}
}
Enhancers establish spatial or temporal patterns of gene expression that are critical for development, yet our understanding of how these DNA cis-regulatory elements function from a distance to increase transcription of their target genes and shape the cellular transcriptome has been gleaned primarily from studies of individual genes or gene families. High-throughput sequencing studies place enhancer-gene interactions within the 3D context of chromosome folding, inviting a new look at enhancer… CONTINUE READING